Friday, 02 June 2023

Blood test finds toxic Alzheimer's proteins

Thursday, 01 February 2018 15:52 Written by  font size decrease font size decrease font size increase font size increase font size

Scientists in Japan and Australia have developed a blood test that can detect the build-up of toxic proteins linked to Alzheimer's disease.

The work, published in the journal Nature, is an important step towards a blood test for dementia.

The test was 90% accurate when trialled on healthy people, those with memory loss and Alzheimer's patients.

Experts said the approach was at an early stage and needed further testing, but was still very promising.

Brain scans
Alzheimer's disease starts years before patients have any symptoms of memory loss.

The key to treating the dementia will be getting in early before the permanent loss of brain cells.

This is why there is a huge amount of research into tests for Alzheimer's.

One method is to look for a toxic protein - called amyloid beta - that builds up in the brain during the disease.

It can be detected with brain scans, but these are expensive and impractical.

'Major implications'
The new approach, a collaboration among universities in Japan and Australia, looks for fragments of amyloid that end up in the blood stream.

By assessing the ratios of types of amyloid fragment, the researchers could accurately predict levels of amyloid beta in the brain.

Significantly, the study shows it is possible to look in the blood to see what is happening in the brain.

Dr Abdul Hye, from King's College London, said: "This study has major implications as it is the first time a group has shown a strong association of blood plasma amyloid with brain and cerebrospinal fluid."

Early stages
The test is cheaper than brain scanning, "potentially enabling broader clinical access and efficient population screening", according to the study.

At the moment there is no treatment to change the course of Alzheimer's, so any test would have limited use for patients.

However, it could be useful in clinical trials.

Prof Tara Spires-Jones, from the Centre for Discovery Brain Sciences, at the University of Edinburgh, said: "These data are very promising and may be incredibly useful in the future, in particular for choosing which people are suited for clinical trials and for measuring whether amyloid levels are changed by treatments in trials."

Dr Hye added: "Considering Alzheimer's disease has a very long pre-clinical phase, a truer test will be how well this test performs in independent, healthy, cognitively normal individuals or even in individuals in the early stages of the disease."

Read 352 times
Rate this item
(0 votes)
Login to post comments
Post-Brexit talks: We'll find ...
Five dead in Milwaukee ...
Trump names VP Pence to lead ...
Post-Brexit talks: UK ...
Coronavirus: Two new cases ...
Greek protests: Dozens hurt ...
Budget 2020: Chancellor must ...
Health officials: Coronavirus ...

Features


cache/resized/42ad9aebc0ade9bb1e09d84bdbde68f2.jpg
A man has been
cache/resized/f581ce10554be9d86c5e1bdbb21518bf.jpg
Researchers say
cache/resized/0a665575691932a2d0ffe8e0f3d1a88f.jpg
A law introducing
cache/resized/bdf1c5362e4a36745bbd1d9da16809f1.jpg
US scientists are
cache/resized/d8402c0a2a72bd474b938d6ac8d61dc4.jpg
The Yazidi

Last News

To read the latest news from U.S & Canada click here.

To read the latest news from Europe click here.

To read the latest news from Latin America click here.

Hot News

Featured photos and videos

cache/resized/3e67a9c6770528a4c259003210c03b14.jpg
One show at Paris Fashion Week proved to be
cache/resized/c884d90e041f3f50ae115fb221fec0cd.jpg
Saudi Arabia has temporarily halted the entry of
cache/resized/7f8b04ffdc0836217221f7aceae27f2a.jpg
Taylor Swift plays a man-spreading, cigar
cache/resized/7888c18e2b426c21e9d55b33fbac28c0.jpg
Five people have been killed in a shooting at the
cache/resized/641c73bdf505f859c217b3555ca823cb.jpg
President Donald Trump has appointed
cache/resized/43b8a9fa9c18aefbe1472ee4cbdaeb52.jpg
Two more patients have tested positive for
cache/resized/91254e011b5304843ebf8d92bddbe4d3.jpg
More than 60 people have been hurt, many of them
cache/resized/872cb2144118b879fa72ea650687959c.jpg
At least 20 civilians, including nine children,
Template Settings

Color

For each color, the params below will give default values
Black Blue Brow Green Cyan

Body

Background Color
Text Color
Layout Style
Select menu
Google Font
Body Font-size
Body Font-family